Research Direction Focusing on the construction of efficient discovery systems for marine natural cyclic peptides, structural identification, and functional mechanism research Research Achievements Established efficient tracking technology for trace novel marine cyclic peptides, innovatively developed neutral loss/precursor ion scanning strategies, and built a standard mass spectrometry library containing 538 marine peptides and a mass spectrometry-guided separation system. Over the past 10 years, more than 100 new cyclic peptides have been discovered from marine sponges, 4 classes of rare novel skeletons have been elucidated, and the antitumor and immunosuppressive mechanisms of 4 active molecules have been clarified; broke through the bottleneck of drug sources, achieved large-scale synthesis of lead compounds such as PF-A and AL-A, providing key methods and material support for the research and development of marine peptide drugs. Published more than 40 SCI papers, including 18 as first author/corresponding author, in authoritative journals such as Org. Lett., J. Nat. Prod., Bioorg. Chem.; obtained 4 authorized Chinese invention patents. Presided over 5 national-level projects, including 3 sub-tasks of the National Key Research and Development Program, and 1 General Program and 1 Youth Program of the National Natural Science Foundation of China.