**Graduation Date:** June 1991
**Research Grants:** Currently or previously served as Principal Investigator for 3 national-level and 4 provincial/ministerial-level projects.
1. Regulatory effect of AKT signaling pathway on CSF-1 and RANTES expression in lupus nephritis. National Natural Science Foundation of China, 2000 (Principal Investigator).
2. Regulatory effect of cytoskeleton-associated proteins on T cell lipid raft changes in SLE patients. National Natural Science Foundation of China, 2006 (Principal Investigator).
3. Regulatory effect of cytoskeleton-associated proteins on synovial angiogenesis in rheumatoid arthritis. National Natural Science Foundation of China, 2007 (Principal Investigator).
4. Therapeutic effect of artemisinin and its derivatives on rheumatoid arthritis. Guangdong Provincial Science and Technology Plan (Key Project), 2006 (Principal Investigator).
5. Effect of inhibiting Rho/ROK pathway on immune and pathological changes in experimental lupus nephritis. Ministry of Education Scientific Research Foundation for Returned Overseas Chinese Scholars, 2006 (Principal Investigator).
6. Regulatory effect of RhoA/ROK pathway on synovial inflammation in rheumatoid arthritis. Guangdong Provincial Natural Science Foundation, 2007 (Principal Investigator).
**Professional Affiliations:** Youth Committee Member, Chinese Rheumatology Association; Standing Committee Member, Rheumatology and Immunology Working Committee, Guangdong Medical Doctor Association.
**Awards:** Participated in research projects that received one Second Prize of the National Science and Technology Progress Award, one Second Prize of the Chinese Medical Science and Technology Award, and one Second Prize of the Guangdong Provincial Science and Technology Progress Award.
**Publications:**
1. Xu H (corresponding author), He Y, Yang X, et al. Anti-malarial agent artesunate inhibits TNF-α-induced production of proinflammatory cytokines via inhibition of NF-κB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. *Rheumatology*, 2007, 46: 920-926.
2. Xu H (corresponding author), Liu P, Liang L, et al. RhoA-mediated TNF-α-induced Activation of Nuclear Factor κB in Rheumatoid Synoviocytes: Inhibitory Effect of Simvastatin. *Arthritis Rheum*, 2006, 54: 3441-3451.
3. Xu H, Zeng L, Hui P, et al. HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. *Am J Physiol Renal Physiol*, 2006, 291: F995-1004.
4. Xu Hanshi, Yang Xiuyan, Liang Liuqin, et al. Regulatory effect of RhoA/ROK signaling pathway on cytokine secretion by LPS-induced human peripheral blood monocytes. *Chinese Journal of Microbiology and Immunology*, 2006, 26: 224-227.
5. Xu Hanshi, Yang Xiuyan, Liang Liuqin, et al. CSF-1 expression in renal tissue of chronic GvHD lupus-like mice and the regulatory effect of prednisone. *Chinese Journal of Rheumatology*, 2003, 7: 402-406.
6. Xu Hanshi, Yang Xiuyan, Liang Liuqin, et al. AKT signaling pathway protein expression in renal tissue of chronic graft-versus-host disease lupus-like mice and the regulatory effect of prednisone. *Chinese Journal of Pathophysiology*, 2003, 19: 1305-1310.
7. Ye Yujin, Xu Hanshi (corresponding author), Liang Liuqin, et al. Regulation of IFN-γ on BLyS gene expression in peripheral blood PBMCs of SLE patients. *Chinese Journal of Rheumatology*, 2006, 10: 577-579.
**Monograph:** Lupus Erythematosus (Associate Editor-in-Chief)
العربية
