Graduated from the Department of Medicine, Shanghai Second Medical College in 1962. From 1983 to 1985, received a WHO fellowship to conduct research on chronic airway diseases at McGill University, Canada. Served as Director of the Department of Pulmonary Medicine, Ruijin Hospital, Shanghai Second Medical University; doctoral supervisor; Deputy Editor-in-Chief of the Chinese Journal of Tuberculosis and Respiratory Diseases; Chairman and Advisor of the Respiratory Society of Shanghai Medical Association; and Vice Chairman of the Critical Care Medicine Specialty Committee of Shanghai Medical Association. Long engaged in research on clinical respiratory emergency care, respiratory support, respiratory dynamics, respiratory regulation during sleep, and other respiratory physiology and monitoring. First in China to conduct clinical measurement of intrinsic positive end-expiratory pressure during mechanical ventilation, as well as moderate permissive hypercapnia ventilation therapy for severe asthma and respiratory dynamics monitoring. In sleep respiratory function research, established testing devices early in China through self-reliance, presided over and completed the National Natural Science Foundation project "Research on Obstructive Sleep Disordered Breathing and Central Respiratory Regulation Mechanisms" and the Ministry of Health research fund project "Investigation and Prevention of Non-Insulin-Dependent Diabetes Mellitus Complicated with Sleep Apnea Syndrome," and was the first in China to report "Clinical Characteristics of Sleep Disordered Breathing Complicated by Acute Respiratory Failure." In recent years, mainly engaged in research on the pathogenesis, susceptibility, prevention and treatment of COPD. Received Shanghai Municipal Science and Technology Progress Award and Shanghai Medical Science and Technology Award multiple times. Published more than 150 papers in core journals at home and abroad, and contributed to more than 50 academic books.